{"id":1174,"date":"2022-06-01T16:02:38","date_gmt":"2022-06-01T14:02:38","guid":{"rendered":"https:\/\/potent.org.rs\/?page_id=1174"},"modified":"2024-01-19T18:48:07","modified_gmt":"2024-01-19T17:48:07","slug":"nuspojave-rezitencija-i-interakcije-prep-a","status":"publish","type":"page","link":"https:\/\/potent.org.rs\/en\/nuspojave-rezitencija-i-interakcije-prep-a\/","title":{"rendered":"Side effects, resistance and interactions of PrEP"},"content":{"rendered":"

Bratislav Proki\u0107, maj 2023.
Reviewers: Dr. Biljana Begovi\u0107 Vuksanovi\u0107 - Belgrade City Institute for Public Health
Dr. Marko Markovi\u0107 - Clinic for Infectious and Tropical Diseases, UCC of Serbia<\/p>\n\n\n\n

What are the most common side effects of PrEP?<\/h2>\n\n\n\n

Mild nausea, diarrhea, bloating and headache may occur at the start of PrEP (occurs in less than 1 in 10 people). These side effects usually stop in a few days or weeks, as the body gets used to the drug.<\/p>\n\n\n\n

Koja su mogu\u0107a ozbiljnija ne\u017eeljena dejstva PrEP-a?<\/h2>\n\n\n\n

Kod malog broja korisnika PrEP mo\u017ee imati negativan efekat na bubrege. \u0160teta se mo\u017ee izbe\u0107i redovnom kontrolom bubre\u017ene funkcije i prekidom kori\u0161\u0107enja u slu\u010daju pojave znakova smanjene bubre\u017ene funkcije.

Tokom prve godine upotrebe PrEP-a, mo\u017ee do\u0107i do blage demineralizacije kostiju. Ovaj efekat je jako mali i ne uti\u010de na krhkost kostiju. Efekat je reverzibilan nakon prestanka sa kori\u0161\u0107enjem PrEP-a.<\/p>\n\n\n\n

Resistance to PrEP<\/h2>\n\n\n\n

U svetu je zabele\u017een manji broj slu\u010daja inficiranja korisnika PrEP-a, uprkos pravilnoj upotrebi. Uzrok tome mo\u017ee biti izlo\u017eenost soju virusa koji je otporan na PrEP, ili rana HIV infekcija koja nije detektovana pre zapo\u010dinjanja sa PrEP-om.<\/p>\n\n\n\n

What is PrEP resistance?<\/h2>\n\n\n\n

PrEP je antiretrovirusni lek koji se u kombinaciji sa drugim lekovima koristi i u le\u010denju HIV infekcije. PrEP ne mo\u017ee u potpunosti da potisne virus kod osobe koja ve\u0107 ima HIV, ili se tokom kori\u0161\u0107enja PrEP-a inficira.

Virus bi, u slu\u010daju da inficirana osoba koristi PrEP, nastavio da se razmo\u017eava, da mutira i stvori otpornost (rezistenciju) na ovaj lek i on se vi\u0161e mo\u017ee koristiti u daljem le\u010denju. \u0160ta vi\u0161e, rezistentan soj virusa bi mogao da se prenosi dalje i da ugrozi druge korisnike PrEP-a.<\/p>\n\n\n\n

How to prevent resistance to PrEP?<\/h2>\n\n\n\n

Rezistenciju mo\u017ee\u0161 spre\u010diti testiranjem na HIV pre i tokom kori\u0161\u0107enja PrEP-a, kao i pravilnom upotrebom.
Tips for preventing resistance:
1. Obavi savetovanje i testiranje na HIV pre zapo\u010dinjanja sa PrEP-om.
2. Redovno i pravilno koristiti PrEP.
3, Obavljaj testiranje na HIV na svaka tri meseca tokom kori\u0161\u0107enja.
4. Prestani sa kori\u0161\u0107enjem u slu\u010daju pojave simptoma HIV infekcije.
5. Potra\u017ei pomo\u0107 i podr\u0161ku ako ima\u0161 problem sa pravilnom upotrebom.<\/p>\n\n\n\n

Da li PrEP ima interakciju sa drugim lekovima?<\/h2>\n\n\n\n

PPrEP nema interakciju s ve\u0107inom drugih lekova, osim sa nekim nesteroidnim protivuplanim lekovima poput ibuprofena (Brufen\u00ae) i neproksena ili sa nestereoidnim antireumatikom: diklofenakom (Diklofen\u00ae). \u010cesta upotreba ovih lekova uz PrEP mo\u017ee izazvati probleme sa bubrezima. Ako koristi\u0161 neke lekove uz PrEP, posavetuj se sa lekarom.<\/p>\n\n\n\n

Check PrEP drug and drug interactions \u00a0online,<\/a>, ili skini aplikaciju za\u00a0iPhone\u00a0<\/a>or\u00a0Android<\/a>. U prvoj koloni izaberi Emticitabine\/Tenofovir-DF (PrEP), u drugoj generi\u010dki naziv drugog leka koji uzima\u0161.<\/p>\n\n\n\n

Termin za testiranje i savetovanje o PrEP-u zaka\u017ei\u00a0ovde<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"

Bratislav Proki\u0107, maj 2023.Recenzenti: dr Biljana Begovi\u0107 Vuksanovi\u0107 \u2013 Gradski<\/p>","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1174","page","type-page","status-publish","hentry"],"yoast_head":"\nNuspojave, rezitencija i interakcije PrEP-a - POTENT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/potent.org.rs\/en\/nuspojave-rezitencija-i-interakcije-prep-a\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuspojave, rezitencija i interakcije PrEP-a - POTENT\" \/>\n<meta property=\"og:description\" content=\"Bratislav Proki\u0107, maj 2023.Recenzenti: dr Biljana Begovi\u0107 Vuksanovi\u0107 \u2013 Gradski\" \/>\n<meta property=\"og:url\" content=\"https:\/\/potent.org.rs\/en\/nuspojave-rezitencija-i-interakcije-prep-a\/\" \/>\n<meta property=\"og:site_name\" content=\"POTENT\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/potent.udruzenje\/\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-19T17:48:07+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/potent.org.rs\/nuspojave-rezitencija-i-interakcije-prep-a\/\",\"url\":\"https:\/\/potent.org.rs\/nuspojave-rezitencija-i-interakcije-prep-a\/\",\"name\":\"Nuspojave, rezitencija i interakcije PrEP-a - 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